COVID-19 vaccine may help people with heart failure live longer, study finds

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Heart failure patients who are vaccinated against COVID-19 are more likely to survive longer than those who are vaccinated against COVID-19, according to research presented at Heart Failure 2024, a scientific conference of the European Society of Cardiology (ESC). 82% more than those who have not been vaccinated. -14 May in Lisbon, Portugal. Heart failure is a life-threatening syndrome that affects more than 64 million people worldwide.

“Patients with heart failure should be vaccinated against COVID-19 to protect their health,” said study author Dr. Kyeong-hyeon Chun of the National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea.

“In this large study of patients with heart failure, COVID-19 vaccination was associated with a reduced likelihood of contracting the infection, being hospitalized due to heart failure, or having any cause during a six-month period “, than living without vaccination.”

Previous studies have shown the safety of COVID-19 vaccination in patients with cardiovascular disease, including heart failure, and the outcomes of COVID-19 vaccination in patients with heart failure compared to patients without heart failure. Are bad. However, there is little research on how the vaccines work specifically in patients with heart failure. This nationwide, retrospective study examined the prognosis of heart failure patients according to COVID-19 vaccination status.

This study used the Korean National Health Insurance Service database, which covers almost all residents of the Republic of Korea, to obtain information on vaccination and clinical outcomes. Participants who received two or more doses of a COVID-19 vaccine were defined as “vaccinated” and those who were not vaccinated or received only one dose were defined as “non-vaccinated.” it was done.

The study included 651,127 patients with heart failure aged 18 years or older. The mean age was 69.5 years and 50% were female. Of the total study population, 538,434 (83%) were defined as vaccinated and 112,693 (17%) were defined as unvaccinated.

To control for factors that might influence the association between vaccination status and outcomes, researchers stratified the vaccinated and non-vaccinated according to age, sex, other health conditions (such as high blood pressure, diabetes, high cholesterol, etc.) The patients were matched 1:1. , income, and area of ​​residence. This resulted in 73,559 vaccinated patients and 73,559 unvaccinated patients included for comparative analysis.

The average follow-up was six months. Vaccination led to an 82% lower risk of all-cause mortality, a 47% lower risk of hospitalization for heart failure, and a 13% lower risk of COVID-19 infection compared with no vaccination. With regard to cardiovascular complications, vaccination was associated with a significantly reduced risk of stroke, heart attack, myocarditis/pericarditis and venous thromboembolism compared to no vaccination.

“This was the first analysis of COVID-19 vaccine effectiveness in a large population of heart failure patients, and the first analysis to show a clear benefit from vaccination,” Dr. Chun said. Provides strong evidence to support this. However, this evidence may not apply to all patients with heart failure, and the risks of vaccination should be considered in patients with unstable conditions.”

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