Genetic code for rare kidney cancer: Research Health

For the first time, the inherited characteristics of reninoma, a rare form of kidney cancer, have been investigated. Researchers from the Wellcome Sanger Institute, Great Ormond Street Hospital and The Royal Free Hospital have also identified a potential medicinal target that could be used as an alternative to surgery in the new report.

The genetic code of rare kidney cancer: research (Pixabay)

The findings were published in Nature Communications.

Reninoma is one of the rarest cancers in humans, with approximately 100 cases identified globally so far (1). Although it can usually be treated with surgery, it can still spread and produce metastases or cause severe hypertension. Reninomas are currently treated only by surgery as there is no drug treatment available. This was unknown till now.

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Researchers found that the development of this rare cancer is caused by a specific error in the genetic code of the cancer gene NOTCH1.

Also read: Kidney Cancer: Causes, Diagnosis, Drawbacks of Traditional Surgery, Treatment

The team examined two cancer samples — from a young adult and a child (2) — with advanced genomic techniques, known as whole genome and single nuclear sequencing (3). Their findings suggest that the use of existing drugs targeting this specific gene is a potential solution to treating reninoma for patients where surgery is not a viable option.

Taryn Traeger, first author of the study and The Little Princess Trust Fellow at the Wellcome Sanger Institute, said: “Many cancerous tumors have already been understood with genomic technologies, however, this is not the case for rare cancers, particularly those affecting children. That’s not true in cancer. Our work aims to fill that gap. This is the first time we’ve identified risk factors for reninoma and we hope our work paves the way toward new treatments for childhood cancer. Will remain.

Dr Tanjina Chowdhury, co-lead author of the study at Great Ormond Street Hospital, said: “The rare kidney cancer known as reninoma does not respond to traditional anti-cancer treatments. The only known treatment at this time is surgery. Our study shows that, in fact, there is a specific and well-studied gene that drives this rare cancer. If we use drugs already known to affect this gene, we may be able to treat it without the need for invasive techniques like surgery.

Co-lead author of the study, Dr Sam Behajati, Wellcome Senior Research Fellow at the Wellcome Sanger Institute and Honorary Consultant Pediatric Oncologist at Addenbrooke’s Hospital, said: “Rare cancers are extremely challenging to study, and patients with such tumors may not benefit from is from cancer research. Here, we have a powerful example of cutting-edge science that is rewriting our understanding of an extremely rare tumor type, carcinoma, along with findings that potentially have immediate implications for patients. There is clinical benefit.

Phil Brace, chief executive of The Little Princess Trust, said: “We are all committed to funding research to discover more effective treatments for childhood cancer and so we are delighted to hear about what has been discovered. We also want to help researchers find compassionate solutions for young people and so we’re very pleased to hear that there may be ways to treat this rare kidney cancer without the need for surgery.

This story is published from a wire agency feed without any modifications to the text. Only the headline has been changed.

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