Global study of more than 99 million people reveals two new rare Covid vaccine side effects

A global study of more than 99 million people in eight countries has identified two new harmful but very rare side effects of COVID-19 vaccines, a step that could lead to better health monitoring of immunized people.

Researchers from an international collaboration called the Global Vaccine Data Network (GVDN), organized at the University of Auckland, assessed 13 neurological, blood and cardiovascular medical conditions to see whether patients were at higher risk of them after receiving Covid. 19 commentary.

The study evaluated anonymized data from millions of people who received a COVID-19 vaccine, and examined whether there was a higher risk of developing a medical condition at different periods after receiving the vaccine compared to before the vaccine became available .

It found that some patients had heart inflammatory conditions such as myocarditis and pericarditis after taking mRNA vaccines, and some had muscle-weakening Guillain-Barré syndrome and a type of blood clot in the brain after taking viral vector vaccines. .

Researchers also found symptoms of inflammation of part of the spinal cord (transverse myelitis), as well as inflammation and swelling of the brain and spinal cord – also called acute disseminated encephalomyelitis – after receiving viral vector vaccines. After some people took viral vector and mRNA vaccines.

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However, scientists say the likelihood of having a neurological event after infection with the novel coronavirus was 617 times higher than after COVID-19 vaccination, suggesting that “the benefits of vaccination far outweigh the risks.”

“This multi-country analysis confirmed pre-established safety signals for myocarditis, pericarditis, Guillain-Barré syndrome, and cerebral venous sinus thrombosis,” the scientists wrote, adding that “other potential safety signals” require further study. Identified.

“The size of the population in this study increases the likelihood of identifying rare potential vaccine safety signals. It is unlikely to have such a large population to detect very rare signals in single sites or areas,” study co-author Kristina Foxova said in a statement.

Researchers are conducting further studies using big data to advance the current understanding of COVID-19 vaccines to better understand their safety.

“By making the data dashboard publicly available, we are able to support greater transparency and stronger communication to the health sector and the public,” said Helen Petousis-Harris, another author of the study.

While the study identified rare safety signals following COVID-19 vaccination, scientists say “further investigation is necessary to confirm associations and assess the clinical significance” of these findings.

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