How obesity affects metabolic syndrome risk and mortality


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Researchers report that obesity and metabolic syndrome have different effects on breast cancer risk. redrooster2/Getty Images
  • In a new study, researchers report that higher metabolic scores are linked to higher mortality rates from breast cancer.
  • They said obesity was associated with a higher incidence of breast cancer.
  • He said a low-fat diet could reduce breast cancer mortality.

A new study shows a strong but distinct link between metabolic syndrome and obesity and breast cancer.

A high metabolic syndrome score was associated with higher mortality from breast cancer and obesity was associated with a higher incidence of breast cancer, according to a Study Published today in the journal cancer,

In it, researchers looked at information from 63,330 women who had no previous breast cancer who received annual mammograms and who were enrolled in the Women's Health Initiative to help determine the impact of obesity and metabolic syndrome on breast cancer after menopause. Was included in.

The study follow-up period was approximately 20 years. Study outcomes included breast cancer incidence, mortality, death after breast cancer diagnosis, and hormone receptor status.

During the study period, there were 4,562 cases of breast cancer and 2,073 deaths following a breast cancer diagnosis, and 659 deaths from breast cancer.

At the beginning of the study, scientists collected the following information:

  • Body Mass Index (BMI)
  • Metabolic score (0, 1-2, 3-4) including waist circumference, blood sugar, blood pressure and cholesterol

At the end of their study, the researchers concluded that metabolic syndrome and obesity both influence breast cancer.

However, he pointed out that there were important differences.

After adjustment for BMI, a higher metabolic score (3–4) was associated with more poor-prognosis estrogen-receptor (ER)-positive, progesterone receptor (PR)-negative breast cancer. Higher metabolic scores were also associated with 53% more deaths after breast cancer diagnosis and 44% higher breast cancer mortality.

After adjusting for metabolic score, obesity was associated with more breast cancer overall, including ER-positive, PR-positive breast cancer with a more good prognosis. Obesity was associated with more deaths after breast cancer diagnosis, with only women with severe obesity having higher mortality rates from breast cancer.

Researchers said a low-fat diet may reduce breast cancer mortality, especially in women who have greater metabolic syndrome components such as obesity, high blood pressure, elevated blood sugar and abnormal cholesterol.

“Obesity, as well as high blood pressure, diabetes and high cholesterol, can both increase the incidence of breast cancer,” said Dr. Parveen Peddie, M.D., medical oncologist and director of breast medical oncology at the Margie Peterson Breast Center at Providence St. John's. Health Center as well as Associate Professor of Medical Oncology at St. John's Cancer Institute in California. “A composite score that takes into account the presence of hypertension, diabetes, high cholesterol and high waist circumference (MeTs) was associated with worse breast cancer (ER positive and PR negative).”

“This means that obesity, if it also causes high blood pressure, diabetes and high cholesterol, is an even worse prognostic factor,” said Peddie, who was not involved in the study. medical news today,

The authors noted that black women have a higher prevalence of aggressive, triple-negative breast cancer and severe obesity.

The scientists concluded that targeting obesity would have a more significant impact on breast cancer incidence and that targeting metabolic syndrome would have a more significant impact on breast cancer mortality.

“It doesn't mean that one is more important than the other,” said Dr. Jack Jacob, a medical oncologist and medical director of the Memorial Care Cancer Institute at Orange Coast Medical Center in California, who was not involved in the study.

“Both are important but in different ways,” Jacob said. medical news today, “This study shows that the parameters we typically associate with heart disease – obesity, blood pressure, blood sugar and cholesterol – are also related to cancer. There are many health variables that are not under our control – such as genes, but metabolic components are. Diet, lifestyle and medications can help control these factors.”

The study confirms that both obesity and metabolic syndrome increase our “breast cancer health burden,” but according to medical oncologist Dr. Douglas Marks, there is at least a difference for each risk factor in relation to breast cancer outcomes. Partially support separate joins. Medical director of the Office of Clinical Trials at NYU Langone Perlmutter Cancer Center-Long Island.

“These observations, in addition to providing additional insight into the biology of breast cancer. “Could influence future pharmacologic and non-pharmacologic interventions,” Marks, who was not involved in the study, said. medical news today, “Additionally, this study emphasizes that obesity and metabolic syndrome, which are not included in many breast cancer risk prediction models, are important to consider when counseling patients about their breast health.”

Marks said, “While obesity appears to be more closely associated with breast cancer incidence versus the development of high-risk breast cancer subtypes, obese patients still fare worse than their non-obese peers after a breast cancer diagnosis. Exhibited.” “Thus, both obesity and hypermetabolic syndrome are associated with greater 'breast cancer health burden' and neither should be ignored. Based on this data, they said, efforts focused on improving metrics associated with high metabolic syndrome may have the greatest impact in reducing breast cancer mortality in particular.

“This study reiterates the importance of preventive strategies,” Jacob said. “I think it matters less how we control them than whether we keep them controlled. The sooner the better and for as long as possible. We don't yet have information about whether one approach is better than the other. The length of follow-up in this study underscores the message.

“Primary care physicians and OB/GYNs are in the best position to talk about breast cancer prevention,” she said. “Normally, we don't think about cancer prevention in terms of diet, but this study clearly shows that there are ways we can reduce the risk of developing breast cancer.”

,[Metabolic syndrome and obesity] Causes more cancer,'' Peddie said. “Metabolic syndrome leads to worse types of cancer, so [I] If given the choice the focus would be on the latter, but this is a wrong choice as they are so interconnected.

“Losing weight will affect breast cancer risk,” she said. “But, difficulties in losing weight should not stop women from controlling glucose levels, blood pressure and cholesterol with medications. “Doing this will reduce the risk of worse types of breast cancer.”

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