How obesity and metabolic syndrome affect the risks of breast cancer and cancer-related death in women.

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In the Women's Health Initiative (WHI) randomized trial, a low-fat diet reduced breast cancer mortality, especially in women with greater metabolic syndrome (MetS) components (obesity, high blood pressure, high blood sugar, and abnormal cholesterol). In. Analysis of WHI findings indicate that MetS and obesity each have different associations with breast cancer subtype and mortality risk. The findings have been published in the journal cancer,

The analysis included 63,330 postmenopausal WHI clinical trial participants without prior breast cancer as well as normal admission mammograms and MetS scores (0-4). After a mean follow-up of 23.2 years, there were 4,562 breast cancer events and 659 breast cancer deaths (breast cancer mortality).

A higher MetS score (3-4), regardless of obesity, was associated with a 44% greater risk of worse-prognosis, estrogen receptor (ER)-positive, progesterone receptor (PR)-negative breast cancer and breast cancer mortality. Was. Obesity, regardless of MetS score, was associated with more good prognosis, ER-positive, PR-positive cancers. Only women with severe obesity (for example, a woman 5 feet, 6 inches tall after menopause, weighing >218 pounds) had a higher risk of mortality from breast cancer.

Lead author Rowan T. Klebowski, MD, Ph.D. said, “Postmenopausal women with high MetS scores are a previously unrecognized population at high breast cancer mortality risk.” of the Lundquist Institute.

“Determining the MetS score in the clinic requires only three questions regarding cholesterol, diabetes and history of hypertension, as well as waist circumference and blood pressure measurements, which are usually determined during routine visits. “

more information:
Rowan T. Klebowski et al, Breast cancer incidence and mortality from metabolic syndrome and obesity: Women's Health Initiative, cancer (2024). DOI: 10.1002/cncr.35318

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