Inflammatory bowel disease slightly increases heart failure risk

Inflammatory bowel disease (IBD) slightly increases the risk of heart failure up to 20 years after diagnosis, according to a comprehensive registry study from Karolinska Institutet in Sweden. European Heart Journal.

As part of the ESPRESSO study, researchers analyzed the risk of heart failure in more than 80,000 patients with inflammatory bowel disease, i.e. Crohn's disease, ulcerative colitis or unclassified IBD, compared with 400,000 people in the general population.

The results show that people with IBD have a 19 percent increased risk of heart failure by 20 years after diagnosis. This corresponds to one additional heart failure case per 130 IBD patients over those 20 years, and the increase in risk was seen regardless of the type of IBD. The highest risk of heart failure was seen in older patients, those with less education, and those with pre-existing cardiovascular disease at IBD diagnosis.

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“Both healthcare providers and patients should be aware of this increased risk, and it is important that cardiovascular health is appropriately monitored,” says study first author Jiangwei Sun, a researcher in the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet. Go.” “We hope that the results will increase healthcare workers' awareness of the increased risk of heart failure in individuals with IBD and contribute to new guidelines for cardiovascular disease management in IBD patients.”

The researchers also analyzed the risk of heart failure in IBD patients compared to their siblings without IBD. In the analysis of these siblings, the risk increase was slightly smaller, 10 percent, suggesting that shared genetics and early environmental factors within families may play a role.

We don't know if there is a causal relationship, but we will continue to explore the role of genetic factors and IBD medications and disease activity on heart failure risk.”

Professor Jonas F. Ludvigsson, senior author of the study from the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet

The study was conducted in collaboration with researchers from Örebro University, the University of Gothenburg and Uppsala University in Sweden.


Journal Reference:

J. Sun, and others, (2024). Risk of heart failure in inflammatory bowel disease: a Swedish population-based study. European Heart

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