Obesity, metabolic syndrome increase risk of breast cancer-related death – study


New Delhi – A high score of metabolic syndrome (MetS), defined as obesity along with high blood pressure, high blood sugar or abnormal cholesterol, may increase the risk of mortality in women with breast cancer, according to a study released Monday. Is.

The findings, published by Wiley Online in CANCER, a peer-reviewed journal of the American Cancer Society, indicate that MetS and obesity each have different associations with breast cancer subtype and mortality risk.

The analysis was based on 63,330 postmenopausal women without prior breast cancer, as well as normal admission mammograms and MetS scores (0-4). After a mean follow-up of 23.2 years, there were 4,562 breast cancer events and 659 breast cancer deaths (breast cancer mortality).

The researchers found that a higher MetS score (3-4) regardless of obesity increased the risk of poor prognosis, estrogen receptor (ER) positive, progesterone receptor (PR) negative breast cancer and had a 44 percent higher risk. Mortality rate from breast cancer.

Obesity, on the other hand, led to more good prognosis, ER-positive and PR-positive cancers, regardless of MetS score.

Only women with severe obesity had a higher risk of death from breast cancer.

“Postmenopausal women with high MetS scores are a previously unrecognized population at high risk of breast cancer mortality,” said lead author Rowan T. Klebowski of The Lundquist Institute in California, US.

Rowan said the MetS score can be easily determined and treated by checking “cholesterol, diabetes and history of high blood pressure, as well as waist circumference and blood pressure measurements” during a routine visit to any health facility. Could.

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