Study confirms infant protection from maternal pertussis vaccination, highlights other effects


A large study looking at the effects of tetanus, diphtheria, and pertussis (Tdap) vaccination during pregnancy found that the effectiveness (VE) of the vaccine at preventing pertussis infection was high in infants younger than 2 months. Although researchers found evidence of stunting in infants after receiving a dose of the vaccine, the team did not find,An increase in cases of whooping cough was found during the first year of life.

mother and child
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The study, published today Pediatrics, involving 279,418 infant-mother pairs across three Australian regions. The researchers looked at administrative health records from 2013 to 2017 for three regions. To assess the impact after infants received diphtheria, tetanus and pertussis DTaP doses, the group examined primary vaccination records from the two largest regions. The vaccine was given to about half of the women in the three regions, usually between 28 and 31 weeks of pregnancy.

The VE from maternal vaccination in infants younger than 2 months was 70.4% (95% confidence interval 50.5% to 82.3%). researchers did,See no difference according to mothers’ gestational age, Vaccination receipt.

However, for infants aged 7 to 8 months, the VE from maternal Tdap decreased to 43.3%, and by 8 months it was no longer effective. Additionally, the team found that infants whose mothers received Tdap had lower VE point estimates for the third dose of infant pertussis vaccine than infants born to unvaccinated mothers, (76.5% vs. 92.9%, P = .0024), suggesting a blunting effect. ,

Previously studying children older than 18 months, researchers found 331 cases of whooping cough, of which 119 cases were in those whose mothers were vaccinated, and 212 cases were in infants who were unvaccinated. are born to mothers with HIV, which suggests less disease in the early months and fewer cases overall during the first few months. 18 months of life.

in a related vaccineKatherine Edwards, MD, professor of pediatrics at Vanderbilt University Medical Center, wrote that the data are encouraging, and more efforts are needed to boost Tdap vaccination levels in pregnant women. he also said,It is important to continue to monitor the consequences of maternal-derived antibodies on infant responses to ensure that blunting has no impact on disease control.

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